Both carry hip dysplasia, hypothyroidism, progressive retinal atrophy and bloat, and both should come from parents with hip scores and current eye certificates. Bloat in particular is worth knowing the signs of in any deep-chested breed: unproductive retching, a swollen tight abdomen, and distress is an emergency measured in hours.
The Akita carries an unusual burden of autoimmune disease — immune-mediated conditions affecting skin, eyes and blood turn up in the breed more than in most, and Vogt-Koyanagi-Harada-like syndrome, which attacks pigment and can affect vision, is associated with it. Ask a breeder about autoimmune history specifically.
The Malamute carries zinc-responsive dermatosis, where the dog absorbs zinc poorly and develops crusting lesions around the face and feet. It is manageable once diagnosed but is frequently mistaken for an allergy first. Inherited polyneuropathy and chondrodysplasia also appear in the breed, and DNA tests exist for both.
Lifespans are close: 10 to 13 years for the Akita, 10 to 14 for the Malamute.