Familial nephropathy is the English Cocker item most worth understanding. It is an inherited kidney disease affecting young dogs — typically between six months and two years — causing progressive renal failure. There is no treatment, and there is a DNA test.
The reason to ask for the result by name rather than accepting a general health assurance is that carriers are healthy. A breeder can honestly say both parents are well and still be mating two carriers, so the only useful answer is the test result itself.
Adult-onset neuropathy is the second, a progressive neurological condition appearing in middle age with an unsteady gait and weakness. It also has a DNA test.
Progressive retinal atrophy and hip dysplasia complete the list, with eye certification and hip scores as the corresponding asks.
The Malamute's own DNA-testable item is inherited polyneuropathy, which shows in young dogs as exercise intolerance, a wobbly or high-stepping gait and a change to the bark. Its list also carries hip and elbow dysplasia, hypothyroidism, hereditary cataracts, progressive retinal atrophy, epilepsy, heart disease, bloat and zinc-responsive skin disease.