Familial Shar-Pei fever is a breed-specific inflammatory condition and it is the most important thing to understand before buying one.
It presents as episodes of high fever, often with a swollen hock joint, lasting a day or two and then resolving on their own. Because the dog recovers without treatment, owners frequently dismiss the first few episodes entirely.
That is the trap. Repeated inflammatory episodes are associated with amyloidosis, in which a protein deposits in the kidneys and liver and progressively destroys function. Renal failure is the usual endpoint and it is not reversible.
Episodes can be treated and their frequency reduced, which is exactly why recognising them early matters. A Shar-Pei with an unexplained fever and a puffy hock should be seen, and the words familial Shar-Pei fever should be said to the vet directly.
Hypothyroidism completes the list, and the breed's 8 to 12 year lifespan reflects the cumulative burden.
The Malamute's list is longer but less insidious: hip and elbow dysplasia, hypothyroidism, hereditary cataracts, progressive retinal atrophy, epilepsy, heart disease, bloat, inherited polyneuropathy and zinc-responsive skin disease.