Collie eye anomaly heads the Rough Collie's condition list. It is an inherited developmental abnormality of the eye, present from birth, ranging from mild and stable to causing retinal detachment and blindness. Puppies can and should be examined by an ophthalmologist at six to eight weeks, and a DNA test exists — ask to see the results.
MDR1 drug sensitivity is the second. Many herding-breed dogs carry a mutation affecting a protein that keeps certain drugs out of the brain, and affected dogs can react severely to normal doses of some common medications including particular wormers and sedatives. The test is cheap, done once, and the result belongs on your vet's file permanently.
Perianal fistula is the third and it is the one owners have usually never heard of — painful ulcerating tracts around the anus, immune-mediated, presenting as straining, licking and reluctance to sit. It responds to modern immunosuppressive treatment far better than it once did, and early recognition matters.
Hip dysplasia, epilepsy, bloat, thyroid disease and cancer complete the list.
The Malamute's own testable item is inherited polyneuropathy, which has a DNA test and shows in young dogs as exercise intolerance and a wobbly gait.