Collie eye anomaly appears on the Border Collie's condition list. It is an inherited developmental abnormality of the eye, present from birth, ranging from mild and stable to causing retinal detachment and blindness. Puppies can be examined by an ophthalmologist at six to eight weeks and there is a DNA test — ask to see the results.
MDR1 drug sensitivity is the second and it will matter in an emergency rather than at purchase. Many herding-breed dogs carry a mutation affecting a protein that keeps certain drugs out of the brain, and affected dogs can react severely to normal doses of some common medications including particular wormers and sedatives. The test is cheap and done once — put the result on your vet's file and volunteer it at every new practice.
Cerebellar abiotrophy is the third, a progressive inherited condition affecting coordination that presents in young dogs and has a test available.
Hip dysplasia, progressive retinal atrophy, epilepsy, hearing problems, allergies, hypothyroidism and cancer complete the list.
The Malamute's own list runs to hip and elbow dysplasia, hypothyroidism, hereditary cataracts, progressive retinal atrophy, epilepsy, heart disease, bloat, inherited polyneuropathy and zinc-responsive skin disease — and polyneuropathy also has a DNA test.