The monthly ranges look close — $150–350 for the Mastiff against $150–300 for the Malamute — but the Mastiff sits at cost level 5/5 and reaches $4,500 in the first year against $4,000, and the real gap is wider than the numbers suggest because the Mastiff's ceiling is where most owners actually land.
Food is the visible part. Feeding a 200 pound dog on a quality diet is a serious monthly line, and giant-breed puppies need controlled calcium and calorie density in the first eighteen months, which narrows the options and raises the price.
The invisible part is weight-based pricing across everything medical. Anaesthesia, sedation, antibiotics, pain relief and parasite prevention are all dosed by kilogram, and a Mastiff can be more than twice a Malamute. A routine dental, a lump removal, a course of anti-inflammatories — each costs proportionally more, every time. Insurance premiums for Mastiff-type breeds are among the highest available, reflecting the cancer, cardiac and orthopaedic entries on the breed's list.
Equipment steps up a tier too: beds, crates, ramps, harnesses, and boarding fees where kennels accept giants at all.
The Malamute's only cost the Mastiff does not carry is grooming — 4/5 against 2/5, and 5/5 shedding against 3/5, meaning an undercoat rake two or three times a week and two heavy annual blows. That is time rather than money if you do it yourself.
Lifespan is the last cost nobody puts in a spreadsheet. The Mastiff's 9 to 11 years against the Malamute's 10 to 14 means a shorter return on everything above, and giant-breed medicine tends to concentrate its expense in the final two years.