The Beagle's list carries cancer at the top, along with hip dysplasia, ear infections, epilepsy, hypothyroidism, obesity, pancreatitis, diabetes, intervertebral disc disease and patellar luxation.
The Malamute's runs to hip and elbow dysplasia, hypothyroidism, hereditary cataracts, progressive retinal atrophy, epilepsy, heart disease, bloat, inherited polyneuropathy and zinc-responsive skin disease. Two of those are worth asking a breeder about by name: polyneuropathy, which has a DNA test and shows in young dogs as exercise intolerance and a wobbly gait, and eye certification for hereditary cataracts.
On money the Beagle runs $80–$150 a month against $150–$300, and $1,300–$2,300 against $2,000–$4,000 in the first year. Food and weight-priced products account for most of the difference, and grooming for the rest — 2/5 against 4/5.
The Beagle also lives longer, 12 to 15 years against 10 to 14.
On balance the Beagle is the substantially cheaper and more housing-flexible dog, and the noisier one.