The two health lists overlap heavily at the top. Hip dysplasia, elbow dysplasia, bloat, hypothyroidism, epilepsy and progressive retinal atrophy appear on both, which makes the breeder conversation almost identical: hip and elbow scoring for both parents, eye certification, and honesty about any seizure history in the line.
Both are large and deep-chested enough that bloat deserves practical planning rather than worry — meals split into two or three, no strenuous exercise in the hour either side of feeding, and a clear idea of where your nearest out-of-hours surgery is. Gastric torsion is measured in hours, not days.
The Wirehaired Pointer's distinctive entry is entropion, an inward-rolling eyelid that turns lashes against the cornea. It is common enough in the breed to be worth asking about, it usually shows in the first year or two, it is surgically corrected, and it is the sort of thing an owner notices as persistent squinting or weeping in one eye rather than as an obvious emergency. The list also includes allergies and recurrent ear infections — the second being a predictable consequence of a working dog that swims and pushes through cover with drop ears.
The Malamute's distinctive entries are zinc-responsive dermatosis, a northern-breed absorption issue that presents as crusting around the muzzle and eyes and responds to supplementation once identified, along with inherited polyneuropathy and hereditary cataracts.
Lifespan is the quiet advantage here. The GWP's 12 to 14 years against the Malamute's 10 to 14 is a meaningful edge for a large breed, and it usually shows up as a longer active middle age rather than a longer decline. Cost tracks size as expected: $110–220 a month against $150–300, with a first year of $1,700–3,000 against $2,000–4,000.