Cerebellar ataxia is the item on the Amstaff's condition list most worth knowing about, and it is unusual in appearing in adulthood rather than puppyhood.
It is an inherited neurodegenerative disease that typically begins between three and five years old in a dog that has been entirely normal. The first signs are subtle coordination problems — a slight wobble, clumsiness on stairs, difficulty judging a jump — and it progresses over months to years into a serious loss of balance and coordination. There is no cure.
The reason to know about it before buying is that there is a DNA test, and a responsible breeder will have used it so that two carriers are never mated together. Ask for both parents' results by name rather than accepting a general assurance that the dogs are healthy — carriers are healthy, which is exactly the problem.
Skin allergies, hip dysplasia, heart disease and cruciate ligament tears complete the list, and skin is the everyday one.
The Malamute's burden is hip and elbow dysplasia, hypothyroidism, hereditary cataracts, progressive retinal atrophy, epilepsy, heart disease, bloat, polyneuropathy and zinc-responsive skin disease.