Monthly heartworm preventives are sold in weight bands, and for most of the familiar products the top band ends somewhere around a hundred pounds. An adult of this breed weighs 120 to 180 pounds. That means the dog does not fit on the chart, and the standard approach is to combine doses under veterinary direction so the animal receives the correct amount of active ingredient for its actual weight.
The practical consequence is that this dog's prevention bill is not the price you see on the shelf. It is that price plus a fraction, or a second smaller unit, every single month, twelve months a year, in the region of the country where skipping is least forgivable. Over a decade that is a real number, and it is the one line where the cheapest market on this list stops being cheap.
Everything else in Jackson genuinely is inexpensive. Routine consultations, vaccinations, boarding and grooming all price well under the national average, and Mississippi's low general costs mean that the space a giant breed requires — a house with room and a yard — is more attainable here than in almost any other metro covered.