Joint dysplasia is not caused by breeding alone, but breeding is the part of it a buyer can influence before the dog exists. The Orthopedic Foundation for Animals maintains public hip and elbow databases; PennHIP offers a separate quantitative hip assessment. A breeder who screens will hand you the sire and dam's evaluations without being asked, and those results are searchable rather than something you have to take on trust.
In a state with this much breeding activity, that request is also a filter. A hobby breeder producing one or two giant litters a year, keeping puppies until eight weeks, and holding certificates on both parents is a different proposition from a volume operation, and the conversation separates them quickly. Nothing about this is adversarial — good breeders enjoy the question, because it is the one that tells them you have read something.
The rest of an Indianapolis budget is genuinely comfortable. Routine veterinary pricing sits under the national average, the parasite-prevention season runs a clearly bounded eight months rather than the year-round schedule a southern city carries, and there is enough space in the metro's housing stock that a giant breed's most basic requirement — floor area — does not carry a coastal premium.