Seek emergency veterinary care if your German Shorthaired Pointer collapses, has trouble breathing, has repeated unproductive retching, develops a swollen or painful abdomen, has a seizure that is new or prolonged, cannot stand, or shows sudden severe weakness or pain. These signs can have many causes, but they should not be explained away as a breed-related genetic concern at home.
For milder but persistent changes such as a recurring limp, stiffness, lower exercise tolerance, vision changes, unusual bleeding, appetite changes, or a notable shift in behavior, arrange a prompt veterinary appointment. Note when the change began and what you observe, then follow the veterinarian's advice on activity and care.
Do not give human medication or use strenuous exercise to test whether your GSP will improve. A veterinary examination is the safest way to determine what the signs may mean for your individual dog.