The Mastiff runs $150–$350 a month and $2,200–$4,500 in the first year, against the Akita's $110–$240 and $1,700–$3,200.
Food is the visible part — a 200-pound dog on a good large-breed diet is a serious monthly line. The invisible part is that almost everything else scales with weight. Parasite treatment, most medications, anaesthesia, joint supplements and boarding are all priced by size, and a course of antibiotics for a Mastiff costs several times what it costs for a mid-sized dog.
The big-ticket risks are correspondingly big. Bloat surgery, cardiac management or an orthopaedic procedure in a giant dog are all four-figure events, and insurance for giant breeds is priced with that in mind — check the excess structure as well as the premium.
Grooming is the one saving, at 2/5 against 3/5.
On exercise the Mastiff needs only 2/5, less than the Akita's 3/5, which makes it a surprisingly undemanding dog to walk once it is grown.